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45 In HepG2 cells, DEM treatment induced NRF2 accumulation under conditions corresponding to mild oxidative stress, whereas higher DEM concentrations corresponding to excessive oxidative stress led to a reduction in NRF2 levels concomitant with induction of ATF4, phospho-JNK, phospho-p38, and phospho-CHK2 (Fig

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CJC-1295 (with DAC) produces a sustained increase in growth hormone and IGF-I, as shown in early pharmacology studies (Teichman et al., 2006)